In APCO 10-codes, 10-81 refers to "Breathalyzer Test."
This code is used primarily by law enforcement to indicate that a breath test is being administered to a suspect, usually in relation to driving under the influence (DUI) cases. When an officer communicates a 10-81, it alerts other officers or dispatch that the subject is undergoing a breath alcohol test to determine their blood alcohol content (BAC).
For example, a radio exchange might look like this: