/li-tᵊl-endē-ən/
adj. Describes a computer architecture in which, within a given 16- or 32-bit word, bytes at lower addresses have lower significance (the word is stored 'little-end-first'). The PDP-11 and VAX families of computers and Intel microprocessors and a lot of communications and networking hardware are little-endian.
See big-endian, middle-endian, NUXI problem.
The term is sometimes used to describe the ordering of units other than bytes; most often these are bits within a byte.